During a manic episode, people often have remarkable energy and move, think, and talk rapidly. They sleep little but do not appear to be tired. They may also experience delusions such as the belief that they are able to fly or are Jesus or another famous person. They may be suspicious that people are out to harm them.
We know that these illnesses are genetic. Nonetheless, some people require yet more proof. Well, welcome to some more proof. Yes, we bipolars are genetically linked to our brothers and sisters with other psychiatric disorders.
Linking of Bipolar, Schizophrenia, Depression and More A new paper out called Shared Molecular Neuropathology Across Major Psychiatric Disorders Parallels Polygenic Overlap now provides more proof these five mental illnesses are genetic and, in fact, even genetically linked and have overlapping expressions in the brain.
I have felt a certain connection to other mental illnesses forever. Straight, unipolar depression is at one end and bipolar disorder type I is at the other. But, of course, there are kinds in the middle like bipolar II and cyclothymia.
Jim Phelps MD, agrees with me and one of his articles on it is here. But just for the record, my father was both an alcoholic and bipolar. Their experiences are not mine, exactly, but I believe I have had a small taste of what autism is like in my own bipolar experiences. Showing Genetic Overlap of Bipolar Disorder, Depression and Schizophrenia How do we know that these overlaps exist beyond my suspicion that they dowell, neurogenetic science, of course.
Gandal et al looked at brains, some with each disorder and then matched controls brains without psychiatric disorders. FYL, only 17 brains had alcoholism, making that link the weakest, in my opinion. These scientists then went on to perform a whole whack of statistical and genetic testing to ensure what they were looking at was only the gene expression overlap for these disorders and not confounding variables.
In my opinion, they were very thorough but also very hard to understand.
Moreover, these scientists even accounted for the effects that antipsychotic medication may have on the brain. They did this by using the brains of primates that were made psychotic and then given antipsychotic medication.
In other words, antipsychotics do, in fact, work to make a brain function more normally. Depression, Bipolar and Schizophrenia Genetic Links In short, what the scientists found was that shared genetic factors underlie this gene expression overlap in bipolar disorder, schizophrenia, depression, autism and alcoholism.
They indicate that most of these effects are likely rooted in genetic risk. Note that they do not say that environmental factors do not play a role — in fact, they note the opposite, environmental factors likely contribute to the variation seen in the brains as not everything to do with the illnesses overlaps in every brain, obviously.
The Effect that Depression, Bipolar and Schizophrenia Genetic Links May Have on Treatment According to The Washington Postby using genetics and what is known about the molecules, scientists can look at mental illness in a whole new way, says Daniel Geschwind, a neurogeneticist and leader of the study.
We think some of it is confused activity. Maybe things are attenuated or jumbled. This is extremely hopeful. Recently, an interviewer asked me if I thought bipolar would be cured in my lifetime. Maybe I was wrong. Maybe these guys are onto something.
Maybe molecular treatment will be available in my lifetime or maybe not. This is exciting and hopeful. She has been living with bipolar disorder for 18 years and has written more than articles on the subject.Introduction Schizophrenia is a serious brain disorder. It is a disease that makes it difficult for a person to tell the difference between real and unreal experience, to think logically, to have normal emotional responses to others, and to behave normally in social situations.
Viral research on schizophrenia and bipolar disorder is thus comparable to viral research on multiple sclerosis and Parkinson's disease: an attractive hypothesis with scattered interesting findings but no clear proof.
Significance and meaning of neurological signs in schizophrenia. Am J Psychiatry. Jan; (1)– . Jan Volavka: VIOLENCE IN SCHIZOPHRENIA AND BIPOLAR DISORDER Psychiatria Danubina, ; Vol. 25, No. 1, pp 24–33 26 Long-term treatment Pharmacological treatment Atypical antipsychotics are the mainstay of the long- term treatment of aggressive behavior in schizophrenia.
Jan 15, · Jan.
15, -- The largest study ever to track bipolar disorder and schizophrenia within families offers evidence that the two psychiatric disorders share a common genetic cause.
Bipolar disorder is a brain disorder marked by periods of elevated mood (mania), and prolonged periods of sadness and hopelessness (depression). These shifts . Bipolar disorder and schizophrenia are two different chronic mental health disorders. People can sometimes mistake the symptoms of bipolar disorder for schizophrenia symptoms.
Read on to learn how.